ARG42790
anti-PLAA / Phospholipase A-2-activating protein antibody
anti-PLAA / Phospholipase A-2-activating protein antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PLAA / Phospholipase A-2-activating protein |
|---|---|
| 反应物种 | Hu |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PLAA / Phospholipase A-2-activating protein |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from Human PLAA / Phospholipase A-2-activating protein. |
| 偶联标记 | Un-conjugated |
| 別名 | PLA2P; PLAP; DOA1; Phospholipase A-2-activating protein |
应用说明
| 应用建议 |
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | MCF7 | ||||||||
| 实际分子量 | ~ 78 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9Y263 Human Phospholipase A-2-activating protein |
|---|---|
| 基因名称 | PLAA |
| 全名 | phospholipase A2-activating protein |
| 生物功能 | Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). Plays a role in cerebellar Purkinje cell development (By similarity). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986). [UniProt] |
| 细胞定位 | Nucleus. Cytoplasm. Cell junction, synapse. Note=Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains. [UniProt] |
| 预测分子量 | 87 kDa |
检测图片 (1) Click the Picture to Zoom In
-
ARG42790 anti-PLAA / Phospholipase A-2-activating protein antibody WB image
Western blot: MCF7 cell lysate stained with ARG42790 anti-PLAA / Phospholipase A-2-activating protein antibody.
