ARG46725
anti-PITX2 / RGS antibody
anti-PITX2 / RGS antibody for Western blot,Flow cytometry and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PITX2 / RGS |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | FACS, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PITX2 / RGS |
| 抗原物种 | Human |
| 抗原 | A synthetic peptide corresponding to a sequence at the N-terminus of PITX2/RGS |
| 偶联标记 | Un-conjugated |
| 別名 | PITX2; Paired Like Homeodomain 2; ARP1; Paired-Like Homeodomain Transcription Factor 2; Otlx2; RIEG1; IGDS; Brx1; RIEG; RGS; RS; ALL1-Responsive Protein ARP1; Homeobox Protein PITX2; Pituitary Homeobox 2; Solurshin; IRID2; IHG2; Rieg Bicoid-Related Homeobox Transcription Factor 1; RIEG Bicoid-Related Homeobox Transcription Factor; Paired-Like Homeodomain 2; All1-Responsive Gene 1; ASGD4; IGDS2; IDG2; PTX2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity chromatography purified |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide and 4% Trehalose. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 4% Trehalose |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PITX2 |
| 全名 | Paired Like Homeodomain 2 |
| 背景介绍 | This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] |
| 生物功能 | May play a role in myoblast differentiation. When unphosphorylated, associates with an ELAVL1-containing complex, which stabilizes cyclin mRNA and ensuring cell proliferation. Phosphorylation by AKT2 impairs this association, leading to CCND1 mRNA destabilization and progression towards differentiation. [UniProt] |
| 细胞定位 | Cytoplasm; Nucleus. [UniProt] |
| 预测分子量 | 35 kDa |
| 翻译后修饰 | Phosphorylated. [UniProt] |
检测图片 (4) Click the Picture to Zoom In
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ARG46725 anti-PITX2 / RGS antibody FACS image
Flow Cytometry: 293T stained with ARG46725 anti-PITX2 / RGS antibody.
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ARG46725 anti-PITX2 / RGS antibody WB image
Western blot: U-87MG stained with ARG46725 anti-PITX2 / RGS antibody.
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ARG46725 anti-PITX2 / RGS antibody WB image
Western blot: Rat heart stained with ARG46725 anti-PITX2 / RGS antibody.
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ARG46725 anti-PITX2 / RGS antibody WB image
Western blot: RAW246.7 stained with ARG46725 anti-PITX2 / RGS antibody.
