概述

产品描述	Rabbit Polyclonal antibody recognizes PITRM1
反应物种	Hu, Ms, Rat
应用	ICC/IF, WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	PITRM1
抗原物种	Human
抗原	Recombinant protein of Human PITRM1
偶联标记	Un-conjugated
別名	Presequence protease, mitochondrial; hPreP; EC 3.4.24.-; Metalloprotease 1; MP1; hMP1; Pitrilysin metalloproteinase 1; PreP

应用说明

应用建议	应用 推荐稀释比 ICC/IF 1:50 - 1:200 WB 1:500 - 1:2000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	U87

属性

形式	Liquid
纯化	Affinity purification with immunogen.
缓冲液	PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 10531 Human PITRM1 GeneID: 69617 Mouse PITRM1 Swiss-port # Q5JRX3 Human Presequence protease, mitochondrial Swiss-port # Q8K411 Mouse Presequence protease, mitochondrial
基因名称	PITRM1
全名	pitrilysin metallopeptidase 1
生物功能	ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. [UniProt]
预测分子量	117 kDa
翻译后修饰	The disulfide bond may lock the enzyme in a closed conformation under oxidized conditions, suggesting that it may participate in redox regulation of the enzyme.

检测图片 (1) Click the Picture to Zoom In