ARG43941
anti-PILRA antibody
anti-PILRA antibody for ELISA,Flow cytometry,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PILRA |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA, FACS, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PILRA |
| 抗原物种 | Human |
| 抗原 | Human PILRA recombinant protein |
| 表达系统 | E.coli |
| 偶联标记 | Un-conjugated |
| Protein Full name | Paired immunoglobulin-like type 2 receptor alpha |
| 別名 | PILRA; Paired Immunoglobin Like Type 2 Receptor Alpha; FDF03; Paired Immunoglobulin-Like Type 2 Receptor Alpha; Inhibitory Receptor PILR-Alpha; Cell Surface Receptor FDF03; Paired Immunoglobin-Like Type 2 Receptor Alpha |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified with Immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4 and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9UKJ1 Human Paired immunoglobulin-like type 2 receptor alpha |
|---|---|
| 基因名称 | PILRA |
| 全名 | Paired Immunoglobin Like Type 2 Receptor Alpha |
| 背景介绍 | Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. |
| 生物功能 | Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP. |
| 细胞定位 | Cell membrane, Membrane, Secreted |
| 预测分子量 | 34 kDa |
| 翻译后修饰 | Glycoprotein, Phosphoprotein |
检测图片 (2) Click the Picture to Zoom In
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ARG43941 anti-PILRA antibody WB image
Western blot: Hela and Jurkat stained with ARG43941 anti-PILRA antibody at 0.5 μg/mL dilution.
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ARG43941 anti-PILRA antibody FACS image
Flow Cytometry: HEL cells stained with ARG43941 anti-PILRA antibody (blue) at 1 μg/1x10^6 cells dilution.
