ARG44891
anti-PIKFYVE antibody
anti-PIKFYVE antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Mouse Monoclonal antibody recognizes PIKFYVE |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG2b |
| 靶点名称 | PIKFYVE |
| 抗原物种 | Human |
| 抗原表位 | AEEGDDNLAN SASPSKRTSV SSFQSTVDSD SAASISLNVE LDNVNFHIKK PSKYPHVPPH PADQKEYLIS DTGGQQLSIS DAFIKESLFN RRVEEKSKEL PFTPLGWHHN NLELLREENG |
| 偶联标记 | Un-conjugated |
| 別名 | PIKFYVE; Phosphoinositide Kinase, FYVE-Type Zinc Finger Containing; KIAA0981; ZFYVE29; PIP5K3; PIP5K; FAB1; Phosphatidylinositol-3-Phosphate/Phosphatidylinositol 5-Kinase, Type III; Phosphatidylinositol 3-Phosphate 5-Kinase Type III; Phosphoinositide Kinase, FYVE Finger Containing ; 1-Phosphatidylinositol 3-Phosphate 5-Kinase; Zinc Finger, FYVE Domain Containing 29; Serine-Protein Kinase PIKFYVE; Type III PIP Kinase; PIPkin-III; MGC40423; P235; FYVE Finger-Containing Phosphoinositide Kinase; Phosphatidylinositol 3-Phosphate 5-Kinase; Epididymis Luminal Protein 37; EC 2.7.1.150; EC 2.7.11.1; PIKfyve; HEL37; CFD |
应用说明
| 应用建议 |
|
||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A purification |
| 缓冲液 | PBS with 0.09% sodium azide |
| 抗菌剂 | 0.09% sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9Y2I7 Human 1-phosphatidylinositol 3-phosphate 5-kinase |
|---|---|
| 基因名称 | PIKFYVE |
| 全名 | Phosphoinositide Kinase, FYVE-Type Zinc Finger Containing |
| 背景介绍 | Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. The protein plays a key role in cell entry of ebola virus and SARS-CoV-2 by endocytosis Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. [provided by RefSeq, Jul 2021] |
| 生物功能 | (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC) by endocytosis. [Uniprot] |
| 细胞定位 | Cytoplasmic vesicle, Endosome, Membrane. [Uniprot] |
| 翻译后修饰 | Acetylation, Phosphoprotein. [Uniprot] |
检测图片 (1) Click the Picture to Zoom In
-
ARG44891 anti-PIKFYVE antibody IHC-P image
Immunohistochemistry: Human kidney stained with ARG44891 anti-PIKFYVE antibody at 10 µg/mL dilution.
