ARG45945
anti-PIK3C2B antibody
anti-PIK3C2B antibody for Western blot and Human,Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PIK3C2B |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PIK3C2B |
| 抗原物种 | Human |
| 抗原 | Recombinant protein containing to human PIK3C2B. |
| 偶联标记 | Un-conjugated |
| 別名 | PIK3C2B; Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 Beta; EC 2.7.1.154; PtdIns-3-kinase C2 subunit beta; PI3K-C2-beta; C2-PI3K; Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta; Phosphoinositide 3-kinase-C2-beta |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 实际分子量 | 160 - 180 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity chromatography purified |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -22°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O00750 Human Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit bet |
|---|---|
| 基因名称 | PIK3C2B |
| 全名 | Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 Beta |
| 背景介绍 | The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008] |
| 生物功能 | Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. [UniProt] |
| 细胞定位 | Nucleus; Cell membrane; Cytoplasm; Microsome; Endoplasmic reticulum; Membrane. [UniProt] |
| 预测分子量 | 185 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG45945 anti-PIK3C2B antibody WB image
Western blot: Hela stained with ARG45945 anti-PIK3C2B antibody at 0.5 μg/ml dilution.
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ARG45945 anti-PIK3C2B antibody WB image
Western blot: Mouse spleen stained with ARG45945 anti-PIK3C2B antibody at 0.5 μg/ml dilution.
