ARG63599
anti-PIK3C2A antibody
anti-PIK3C2A antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Immune System antibody; Signaling Transduction antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes PIK3C2A |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms, Dog |
| 应用 | IHC-P |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PIK3C2A |
| 抗原物种 | Human |
| 抗原 | C-TVKWYQLTAATYL |
| 偶联标记 | Un-conjugated |
| 別名 | EC 2.7.1.154; PI3K-C2-alpha; CPK; PI3-K-C2(ALPHA); Phosphoinositide 3-kinase-C2-alpha; Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; PtdIns-3-kinase C2 subunit alpha; PI3-K-C2A |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Microwaved tissue section in Citrate buffer (pH 6.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by antigen affinity chromatography. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O00443 Human Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alp |
|---|---|
| 背景介绍 | The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008] |
| 研究领域 | Immune System antibody; Signaling Transduction antibody |
| 预测分子量 | 191 kDa |
| 翻译后修饰 | Phosphorylated upon insulin stimulation; which may lead to enzyme activation (By similarity). Phosphorylated on Ser-259 during mitosis and upon UV irradiation; which does not change enzymatic activity but leads to proteasomal degradation. Ser-259 phosphorylation may be mediated by CDK1 or JNK, depending on the physiological state of the cell. |
检测图片 (1) Click the Picture to Zoom In
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ARG63599 anti-PIK3C2A antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human placenta tissue. Antigen Retrieval: Microwaved tissue section in Citrate buffer (pH 6.0). The tissue section was stained with ARG63599 anti-PIK3C2A antibody at 2 µg/ml dilution followed by HRP-staining.
