ARG57978
anti-PIEZO1 / FAM38A antibody
anti-PIEZO1 / FAM38A antibody for ICC/IF,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PIEZO1 / FAM38A |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PIEZO1 / FAM38A |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 2230-2420 of Human PIEZO1. (NP_001136336.2). |
| 偶联标记 | Un-conjugated |
| 別名 | Mib; Piezo-type mechanosensitive ion channel component 1; Membrane protein induced by beta-amyloid treatment; FAM38A; Protein FAM38A; DHS |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | ~ 300 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q0KL00 Rat Piezo-type mechanosensitive ion channel component 1 Swiss-port # Q92508 Human Piezo-type mechanosensitive ion channel component 1 |
|---|---|
| 基因名称 | PIEZO1 |
| 全名 | piezo-type mechanosensitive ion channel component 1 |
| 背景介绍 | The protein encoded by this gene is a mechanically-activated ion channel that links mechanical forces to biological signals. The encoded protein contains 36 transmembrane domains and functions as a homotetramer. Defects in this gene have been associated with dehydrated hereditary stomatocytosis. [provided by RefSeq, Jul 2015] |
| 生物功能 | Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship and are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensors that promote endothelial cell organization and alignment in the direction of blood flow. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology. [UniProt] |
| 细胞定位 | Cell membrane, Cell projection, Endoplasmic reticulum membrane, Endoplasmic reticulum-Golgi intermediate compartment membrane, Multi-pass membrane protein, lamellipodium membrane. [UniProt] |
| 预测分子量 | 287 kDa |
检测图片 (4) Click the Picture to Zoom In
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ARG57978 anti-PIEZO1 / FAM38A antibody WB image
Western blot: HeLa cell lysate stained with ARG57978 anti-PIEZO1 / FAM38A antibody at 1:500 dilution.
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ARG57978 anti-PIEZO1 / FAM38A antibody ICC/IF image
Immunofluorescence: Human MCF7 cells stained with ARG57978 anti-PIEZO1 / FAM38A antibody at 1:100 dilution.
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ARG57978 anti-PIEZO1 / FAM38A antibody ICC/IF image
Immunofluorescence: Mouse NIH-3T3 cells stained with ARG57978 anti-PIEZO1 / FAM38A antibody at 1:100 dilution.
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ARG57978 anti-PIEZO1 / FAM38A antibody ICC/IF image
Immunofluorescence: Rat PC-12 cells stained with ARG57978 anti-PIEZO1 / FAM38A antibody at 1:100 dilution.
