ARG53458
anti-PHLPP2 antibody [SP220]
anti-PHLPP2 antibody [SP220] for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Signaling Transduction antibody
概述
| 产品描述 | Rabbit Monoclonal antibody [SP220] recognizes PHLPP2 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | SP220 |
| 同位型 | IgG |
| 靶点名称 | PHLPP2 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from human PHLPP2 protein. |
| 偶联标记 | Un-conjugated |
| 別名 | PH domain leucine-rich repeat-containing protein phosphatase 2; PHLPP-like; PH domain leucine-rich repeat-containing protein phosphatase-like; PHLPPL; EC 3.1.3.16 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Prostate, Prostate Adenocarcinoma, HEK293T Cell Lysate |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified by protein A/G |
| 缓冲液 | PBS (pH 7.6), 1% BSA and <0.1% Sodium azide |
| 抗菌剂 | <0.1% Sodium azide |
| 稳定剂 | 1% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q6ZVD8 Human PH domain leucine-rich repeat-containing protein phosphatase 2 |
|---|---|
| 基因名称 | PHLPP2 |
| 全名 | PH domain and leucine rich repeat protein phosphatase 2 |
| 生物功能 | Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. [UniProt] |
| 细胞定位 | Cytoplasm, Membrane, Nucleus |
| 研究领域 | Signaling Transduction antibody |
| 预测分子量 | 147 kDa |
检测图片 (3) Click the Picture to Zoom In
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ARG53458 anti-PHLPP2 antibody [SP220] WB image
Western Blot: HEK 293T Cell Lysate stained with PHLPP2 antibody [SP220] (ARG53458)
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ARG53458 anti-PHLPP2 antibody [SP220] IHC-P image
Immunohistochemistry: Human Normal Prostate stained with PHLPP2 antibody [SP220] (ARG53458)
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ARG53458 anti-PHLPP2 antibody [SP220] IHC-P image
Immunohistochemistry: Human Prostate Adenocarcinoma stained with PHLPP2 antibody [SP220] (ARG53458)
