ARG64267
anti-PHLPP2 antibody
anti-PHLPP2 antibody for Western blot and Human
Signaling Transduction antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes PHLPP2 |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PHLPP2 |
| 抗原物种 | Human |
| 抗原 | C-PHEEDRTEPPEEFD |
| 偶联标记 | Un-conjugated |
| 別名 | PH domain leucine-rich repeat-containing protein phosphatase 2; PHLPP-like; PH domain leucine-rich repeat-containing protein phosphatase-like; PHLPPL; EC 3.1.3.16 |
应用说明
| 应用建议 |
|
||||
|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by antigen affinity chromatography. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q6ZVD8 Human PH domain leucine-rich repeat-containing protein phosphatase 2 |
|---|---|
| 基因名称 | PHLPP2 |
| 全名 | PH domain and leucine rich repeat protein phosphatase 2 |
| 生物功能 | Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. [UniProt] |
| 研究领域 | Signaling Transduction antibody |
| 预测分子量 | 147 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG64267 anti-PHLPP2 antibody WB image
Western Blot: Human Brain (Amygdala, Hippocampus, Substantia Nigra) lysate (35 µg protein in RIPA buffer) stained with ARG64267 anti-PHLPP2 antibody at 0.1 µg/ml dilution.
