ARG58675
anti-PHC2 antibody
anti-PHC2 antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PHC2 |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PHC2 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 250-323 of Human PHC2 (NP_004418.2). |
| 偶联标记 | Un-conjugated |
| 別名 | HPH2; hPH2; Polyhomeotic-like protein 2; EDR2; PH2; Early development regulatory protein 2 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | 293T | ||||
| 实际分子量 | 45 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PHC2 |
| 全名 | polyhomeotic homolog 2 (Drosophila) |
| 背景介绍 | In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | 91 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG58675 anti-PHC2 antibody WB image
Western blot: 25 µg of 293T cell lysate stained with ARG58675 anti-PHC2 antibody at 1:3000 dilution.
