ARG44581
anti-PEX19 antibody
anti-PEX19 antibody for Flow cytometry,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PEX19 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PEX19 |
| 抗原物种 | Human |
| 抗原 | Human PEX19 recombinant protein (aa. sequence: Q51-A269). |
| 偶联标记 | Un-conjugated |
| 別名 | PEX19; Peroxisomal Biogenesis Factor 19; HK33; Peroxisomal Farnesylated Protein; D1S2223E; PXMP1; PMP1; PMPI; PXF; 33 KDa Housekeeping Protein; Housekeeping Gene, 33kD; Peroxin-19; PBD12A |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| 抗菌剂 | 4% Trehalose |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PEX19 |
| 全名 | Peroxisomal Biogenesis Factor 19 |
| 背景介绍 | This gene is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. These disorders have at least 14 complementation groups, with more than one phenotype being observed for some complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS), as well as peroxisome biogenesis disorder complementation group 14 (PBD-CG14), which is also known as PBD-CGJ. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010] |
| 生物功能 | Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. [Uniprot] |
| 细胞定位 | Cytoplasm, Membrane, Peroxisome. [Uniprot] |
| 预测分子量 | 33 kDa |
| 翻译后修饰 | Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation. [Uniprot] |
检测图片 (2) Click the Picture to Zoom In
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ARG44581 anti-PEX19 antibody WB image
Western blot: Jurkat, K562 and SiHa stained with ARG44581 anti-PEX19 antibody at 0.5 μg/mL dilution.
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ARG44581 anti-PEX19 antibody FACS image
Flow Cytometry: JK stained with ARG44581 anti-PEX19 antibody at 1 μg/10^6 cells dilution.
