ARG42546
anti-PDIA6 antibody
anti-PDIA6 antibody for Western blot and Human,Mouse,Rat,Dog,Monkey
概述
| 产品描述 | Goat Polyclonal antibody recognizes PDIA6 |
|---|---|
| 反应物种 | Hu, Ms, Rat, Dog, Mk |
| 应用 | WB |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PDIA6 |
| 抗原物种 | Human |
| 抗原 | Recombinant peptide within aa. 220 to the C-terminus of Human PDIA6. |
| 偶联标记 | Un-conjugated |
| 別名 | Protein disulfide isomerase P5; ERP5; Thioredoxin domain-containing protein 7; P5; ER protein 5; Endoplasmic reticulum protein 5; ERp5; EC 5.3.4.1; Protein disulfide-isomerase A6; TXNDC7 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | HeLa and HT1080 | ||||
| 实际分子量 | ~ 49 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS, 0.05% Sodium azide and 20% Glycerol. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 20% Glycerol |
| 浓度 | 3 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PDIA6 |
| 全名 | protein disulfide isomerase family A, member 6 |
| 背景介绍 | This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016] |
| 生物功能 | May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). [UniProt] |
| 细胞定位 | Endoplasmic reticulum lumen. Cell membrane. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545). [UniProt] |
| 预测分子量 | 48 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG42546 anti-PDIA6 antibody WB image
Western blot: 50 µg of HeLa and HT1080 cell lysates stained with ARG42546 anti-PDIA6 antibody at 1:1000 dilution.
