ARG10811

anti-PDE8B antibody

anti-PDE8B antibody for Confocal microscopy (Confocal),Dot blot,ELISA,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat,Bovine,Monkey

publication_link 参考文献1

概述

产品描述 Rabbit Polyclonal antibody recognizes PDE8B
反应物种 Hu, Ms, Rat, Bov, Mk
应用 Confocal, Dot, ELISA, ICC/IF, IHC-P, IP, WB
宿主 Rabbit
克隆 Polyclonal
同位型 IgG
靶点名称 PDE8B
抗原物种 Mouse
抗原 Synthetic cyclic peptide common to all PDE8B variants.
偶联标记 Un-conjugated
別名 EC 3.1.4.53; HsPDE8B; Cell proliferation-inducing gene 22 protein; ADSD; PPNAD3; High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

应用说明

应用建议
应用 推荐稀释比
Confocal1:200
Dot1:10000
ELISA1:10000
ICC/IF1:200
IHC-P1:200
IP1:250
WB1:500 - 1:2000
应用说明 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式 Liquid
纯化 Affinity purified.
缓冲液 Tris-Glycine Buffer (pH 7.4 - 7.8), Hepes, 0.02% Sodium azide, 30% Glycerol and 0.5% BSA.
抗菌剂 0.02% Sodium azide
稳定剂 30% Glycerol and 0.5% BSA
浓度 0.5 mg/ml
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接

GeneID: 8622 Human PDE8B

Swiss-port # O95263 Human High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiest

基因名称 Pde8b
全名 phosphodiesterase 8B
背景介绍 The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
生物功能 Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland. [UniProt]
预测分子量 99 kDa

检测图片 (2) Click the Picture to Zoom In

  • ARG10811 anti-PDE8B antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Human ovarian medulla tissue stained with ARG10811 anti-PDE8B antibody.

  • ARG10811 anti-PDE8B antibody WB image

    Western blot: Rat testis and Rat heart lysates stained with ARG10811 anti-PDE8B antibody at 1:300 dilution.

文献引用

Single-cell transcriptomic analysis identifies downregulated phosphodiesterase 8B as a novel oncogene in IDH-mutant glioma

IHC-P / Human

Zongze He et al.
Front Immunol.,  (2024)

publication_link

 

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