ARG10811
anti-PDE8B antibody
anti-PDE8B antibody for Confocal microscopy (Confocal),Dot blot,ELISA,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat,Bovine,Monkey
参考文献1
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PDE8B |
|---|---|
| 反应物种 | Hu, Ms, Rat, Bov, Mk |
| 应用 | Confocal, Dot, ELISA, ICC/IF, IHC-P, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PDE8B |
| 抗原物种 | Mouse |
| 抗原 | Synthetic cyclic peptide common to all PDE8B variants. |
| 偶联标记 | Un-conjugated |
| 別名 | EC 3.1.4.53; HsPDE8B; Cell proliferation-inducing gene 22 protein; ADSD; PPNAD3; High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | Tris-Glycine Buffer (pH 7.4 - 7.8), Hepes, 0.02% Sodium azide, 30% Glycerol and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 30% Glycerol and 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O95263 Human High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiest |
|---|---|
| 基因名称 | Pde8b |
| 全名 | phosphodiesterase 8B |
| 背景介绍 | The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010] |
| 生物功能 | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland. [UniProt] |
| 预测分子量 | 99 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG10811 anti-PDE8B antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human ovarian medulla tissue stained with ARG10811 anti-PDE8B antibody.
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ARG10811 anti-PDE8B antibody WB image
Western blot: Rat testis and Rat heart lysates stained with ARG10811 anti-PDE8B antibody at 1:300 dilution.
文献引用
Single-cell transcriptomic analysis identifies downregulated phosphodiesterase 8B as a novel oncogene in IDH-mutant glioma
IHC-P / Human
