ARG10786
anti-PDE10A antibody
anti-PDE10A antibody for Confocal microscopy (Confocal),Dot blot,ELISA,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat,Monkey
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PDE10A |
|---|---|
| 反应物种 | Hu, Ms, Rat, Mk |
| 应用 | Confocal, Dot, ELISA, ICC/IF, IHC-P, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PDE10A |
| 抗原物种 | Human |
| 抗原 | Synthetic multiple antigenic peptide around the aa. 250-325 of Human PDE10A. |
| 偶联标记 | Un-conjugated |
| 別名 | HSPDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; EC 3.1.4.17; EC 3.1.4.35 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | Tris-Glycine Buffer (pH 7.4 - 7.8), Hepes, 0.02% Sodium azide, 30% Glycerol and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 30% Glycerol and 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PDE10A |
| 全名 | phosphodiesterase 10A |
| 背景介绍 | The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011] |
| 生物功能 | Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. [UniProt] |
| 预测分子量 | 88 kDa |
| 翻译后修饰 | Isoform PDE10A2: Phosphorylated on Thr-16. |
检测图片 (3) Click the Picture to Zoom In
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ARG10786 anti-PDE10A antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat testis tissue section. A) Negative control, B) Stained with ARG10786 anti-PDE10A antibody at 1:200 dilution.
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ARG10786 anti-PDE10A antibody WB image
Western blot: Rat samples: 1) frontal cortex, 2) parietal cortex, 3) striatum, 4) amygdala, 5) hypothalamus, 6) hippocampus, 7) olfactory bulb, 8) brain stem, 9) cerebellum, 10) spinal cord, and 11) whole brain lysates stained with ARG10786 anti-PDE10A antibody at 1:500 dilution.
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ARG10786 anti-PDE10A antibody WB image
Western blot: Rat striatum lysates stained with ARG10786 anti-PDE10A antibody at 1:500 dilution.
