ARG56518
anti-PCK1 / PEPCKC antibody
anti-PCK1 / PEPCKC antibody for Western blot and Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PCK1 / PEPCKC |
|---|---|
| 反应物种 | Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PCK1 / PEPCKC |
| 抗原物种 | Mouse |
| 抗原 | Synthetic peptide around the N-terminus of Mouse PCK1 / PEPCK-C. |
| 偶联标记 | Un-conjugated |
| 別名 | Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; EC 4.1.1.32; PEPCK1; PEPCK-C; PEPCKC |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | TBS (pH 7.4), 0.02% Sodium azide, 50% Glycerol and 0.1% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol and 0.1% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P07379 Rat Phosphoenolpyruvate carboxykinase, cytosolic [GTP] Swiss-port # Q9Z2V4 Mouse Phosphoenolpyruvate carboxykinase, cytosolic [GTP] |
|---|---|
| 基因名称 | Pck1 |
| 全名 | phosphoenolpyruvate carboxykinase 1, cytosolic |
| 背景介绍 | This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. [provided by RefSeq, Jul 2008] |
| 生物功能 | Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. [UniProt] |
| 预测分子量 | 69 kDa |
| 翻译后修饰 | Lysine acetylation by p300/EP300 is increased on high glucose conditions and promotes ubiquitination by UBR5, acetylation is enhanced in the presence of BAG6. Deacetylated by SIRT2. Ubiquitination by UBR5 leads to proteasomal degradation. |
