ARG40123
anti-PCGF6 antibody
anti-PCGF6 antibody for ICC/IF,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PCGF6 |
|---|---|
| 反应物种 | Hu |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PCGF6 |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 261-295 of Human PCGF6. |
| 偶联标记 | Un-conjugated |
| 別名 | RING finger protein 134; Mel18 and Bmi1-like RING finger; RNF134; Polycomb group RING finger protein 6; MBLR |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Human kidney |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A and immunogen peptide. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide. |
| 抗菌剂 | 0.09% (W/V) Sodium azide. |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9BYE7 Human Polycomb group RING finger protein 6 |
|---|---|
| 基因名称 | PCGF6 |
| 全名 | polycomb group ring finger 6 |
| 背景介绍 | The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| 生物功能 | Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | 39 kDa |
| 翻译后修饰 | Phosphorylated during mitosis. Phosphorylated on Ser-30 by CDK7 in vitro. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG40123 anti-PCGF6 antibody ICC/IF image
Immunofluorescence: HeLa cells stained with ARG40123 anti-PCGF6 antibody (green) at 1:25 dilution. Cytoplasmic actin was counterstained with Alexa Fluor® 555 conjugated with Phalloidin (red).
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ARG40123 anti-PCGF6 antibody WB image
Western blot: 20 µg of Human kidney lysate stained with ARG40123 anti-PCGF6 antibody at 1:1000 dilution.
