ARG40261
anti-PCDH8 antibody
anti-PCDH8 antibody for Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PCDH8 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PCDH8 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 450-750 of Human PCDH8 (NP_002581.2). |
| 偶联标记 | Un-conjugated |
| 別名 | ARCADLIN; Arcadlin; Protocadherin-8; PAPC |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | U-251MG, Mouse brain and Rat brain | ||||
| 实际分子量 | ~ 110 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PCDH8 |
| 全名 | protocadherin 8 |
| 背景介绍 | This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails. [provided by RefSeq, Jul 2008] |
| 生物功能 | Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis (By similarity). [UniProt] |
| 细胞定位 | Cell membrane; Single-pass type I membrane protein. Cell projection, dendrite. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane. Note=Also expressed in neuronal cell bodies. Localized to excitatory, but not with inhibitory, synapses. [UniProt] |
| 预测分子量 | 113 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG40261 anti-PCDH8 antibody WB image
Western blot: 25 µg of U-251MG cell lysate stained with ARG40261 anti-PCDH8 antibody at 1:1000 dilution.
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ARG40261 anti-PCDH8 antibody WB image
Western blot: 25 µg of Rat brain and Mouse brain lysates stained with ARG40261 anti-PCDH8 antibody at 1:1000 dilution.
