概述

产品描述	Rabbit Polyclonal antibody recognizes PCBP1
反应物种	Hu
预测物种	Ms, Bov, Rb
应用	WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	PCBP1
抗原物种	Human
抗原	KLH-conjugated synthetic peptide corresponding to aa. 188-217 (Center) of Human PCBP1.
偶联标记	Un-conjugated
別名	HNRPX; HNRPE1; hnRNP-X; HEL-S-85; hnRNP-E1; Poly(rC)-binding protein 1; Alpha-CP1; Heterogeneous nuclear ribonucleoprotein E1; hnRNP E1; Nucleic acid-binding protein SUB2.3

应用说明

应用建议	应用 推荐稀释比 WB 1:1000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	K562

属性

形式	Liquid
纯化	Purification with Protein A and immunogen peptide.
缓冲液	PBS and 0.09% (W/V) Sodium azide.
抗菌剂	0.09% (W/V) Sodium azide.
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 5093 Human PCBP1 Swiss-port # Q15365 Human Poly(rC)-binding protein 1
基因名称	PCBP1
全名	poly(rC) binding protein 1
背景介绍	This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008]
生物功能	Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. [UniProt]
细胞定位	Nucleus. Cytoplasm. Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm
预测分子量	37 kDa
翻译后修饰	Phosphorylated; lowers poly(rC)-binding activity.

检测图片 (1) Click the Picture to Zoom In