ARG40801
anti-PCBD1 antibody
anti-PCBD1 antibody for ICC/IF,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PCBD1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PCBD1 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-104 of Human PCBD1 (NP_000272.1). |
| 偶联标记 | Un-conjugated |
| 別名 | Pterin carbinolamine dehydratase; Phenylalanine hydroxylase-stimulating protein; EC 4.2.1.96; DCOH; Pterin-4-alpha-carbinolamine dehydratase; PCBD; Dimerization cofactor of HNF1; PHS; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; 4-alpha-hydroxy-tetrahydropterin dehydratase; DCoH; PCD |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | SW620 | ||||||
| 实际分子量 | 12 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PCBD1 |
| 全名 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha |
| 背景介绍 | This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. A deficiency of this enzyme leads to hyperphenylalaninemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
| 生物功能 | Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity. [UniProt] |
| 细胞定位 | Cytoplasm. Nucleus. Note=Cytoplasmic and/or nuclear. [UniProt] |
| 预测分子量 | 12 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG40801 anti-PCBD1 antibody WB image
Western blot: 25 µg of SW620 cell lysate stained with ARG40801 anti-PCBD1 antibody at 1:1000 dilution.
