ARG57923
anti-PBK / TOPK phospho (Thr9) antibody
anti-PBK / TOPK phospho (Thr9) antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PBK / TOPK phospho (Thr9) |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PBK / TOPK |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated phospho peptide corresponding to 2-35 amino acids from Human PBK / TOPK. |
| 偶联标记 | Un-conjugated |
| 別名 | T-LAK cell-originated protein kinase; Nori-3; Spermatogenesis-related protein kinase; PDZ-binding kinase; EC 2.7.12.2; Lymphokine-activated killer T-cell-originated protein kinase; HEL164; SPK; TOPK; MAPKK-like protein kinase; Cancer/testis antigen 84; CT84 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | HeLa + Nocodazole |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A and immunogen peptide. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide. |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q96KB5 Human Lymphokine-activated killer T-cell-originated protein kinase |
|---|---|
| 基因名称 | PBK |
| 全名 | PDZ binding kinase |
| 背景介绍 | This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| 生物功能 | Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. [UniProt] |
| 预测分子量 | 36 kDa |
| 翻译后修饰 | Phosphorylated; in a cell-cycle dependent manner at mitosis. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG57923 anti-PBK / TOPK phospho (Thr9) antibody WB image
Western blot: HeLa cells untreated (right) or treated with Nocodazole at 100 ng/ml (left), and stained with ARG57923 anti-PBK / TOPK phospho (Thr9) antibody.
