ARG46355
anti-PARL antibody
anti-PARL antibody for Western blot,ICC/IF and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PARL |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PARL |
| 抗原物种 | Human |
| 抗原 | A 15 amino acid synthetic peptide within the last 50 amino acids of human PARL. |
| 偶联标记 | Un-conjugated |
| 別名 | presenilin associated, rhomboid-like; PARL; PSARL; PSARL1; RHBDS1; PRO2207; PSENIP2; PSARL; Presenilins-associated rhomboid-like protein; mitochondrial; Mitochondrial intramembrane cleaving protease PARL; Pbeta |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity chromatography purified |
| 缓冲液 | PBS and 0.02% Sodium azide. |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -405°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PARL |
| 全名 | presenilin associated, rhomboid-like |
| 背景介绍 | This gene encodes a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. The encoded protein regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of the encoded protein results in the release of a small peptide, P-beta, which may transit to the nucleus. Mutations in this gene may be associated with Parkinson's disease. [provided by RefSeq, May 2016] |
| 生物功能 | Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). [UniProt] |
| 细胞定位 | Nucleus; Mitochondrion inner membrane. [UniProt] |
| 预测分子量 | 42 kDa |
| 翻译后修饰 | Phosphoprotein. [UniProt] |
