ARG44718
anti-PADI2 / PAD2 antibody
anti-PADI2 / PAD2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation and Human
概述
| 产品描述 | Mouse Monoclonal antibody recognizes PADI2 / PAD2 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, IP |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG2a |
| 靶点名称 | PADI2 / PAD2 |
| 抗原物种 | Human |
| 偶联标记 | Un-conjugated |
| 別名 | EC 3.5.3.15; Peptidylarginine deiminase II; PDI2; Protein-arginine deiminase type II; Protein-arginine deiminase type-2; PAD2; PAD-H19 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A purification |
| 缓冲液 | PBS with 0.09% sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PADI2 |
| 全名 | peptidyl arginine deiminase, type II |
| 背景介绍 | This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008] |
| 生物功能 | Catalyzes the deimination of arginine residues of proteins. [UniProt] |
| 细胞定位 | Cytoplasm. [UniProt] |
| 预测分子量 | 76 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG44718 anti-PADI2 / PAD2 antibody IHC-P image
Immunohistochemistry: Human skeletal muscle stained with ARG44718 anti-PADI2 / PAD2 antibody at 5 µg/mL dilution.
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ARG44718 anti-PADI2 / PAD2 antibody IP image
Immunoprecipitation: AsPC-1 lysate immunoprecipitated with 2.5 µg of ARG44718 anti-PADI2 / PAD2 antibody.
