概述

产品描述	Rabbit Polyclonal antibody recognizes P400
反应物种	Hu
应用	WB
宿主	Rabbit
克隆	Polyclonal
靶点名称	P400
抗原物种	Human
抗原	Recombinant fusion protein of human p400
偶联标记	Un-conjugated
別名	EP400; E1A Binding Protein P400; CAGH32; KIAA1498; KIAA1818; TNRC12; E1A-binding protein p400; CAG repeat protein 32; Domino homolog; hDomino; Trinucleotide repeat-containing gene 12 protein; p400 kDa SWI2/SNF2-related protein

应用说明

应用建议	应用 推荐稀释比 WB 1:500 - 1:2000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
实际分子量	400 kDa

属性

形式	Liquid
纯化	Affinity chromatography purified
缓冲液	0.42% Potassium phosphate, 0.87% NaCl, 0.01% sodium azide, and 30% glycerol.
抗菌剂	0.01% sodium azide
稳定剂	30% glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 57634 Human EP400 Swiss-port # Q96L91 Human E1A-binding protein p400
基因名称	EP400
全名	E1A Binding Protein P400
背景介绍	Predicted to enable chromatin binding activity. Involved in positive regulation of double-strand break repair via homologous recombination and regulation of cell cycle. Part of NuA4 histone acetyltransferase complex; Swr1 complex; and nucleosome. [provided by Alliance of Genome Resources, Jun 2025]
生物功能	Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. [UniProt]
细胞定位	Nucleus. [UniProt]
预测分子量	343 kDa
翻译后修饰	Acetylation; Phosphoprotein. [UniProt]

检测图片 (1) Click the Picture to Zoom In