ARG64981
anti-P2RX7 / P2X7 Receptor antibody
anti-P2RX7 / P2X7 Receptor antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse
Neuroscience antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes P2RX7 / P2X7 Receptor |
|---|---|
| 反应物种 | Hu, Ms |
| 预测物种 | Dog, Rat |
| 应用 | ICC/IF, IHC-P |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | P2RX7 / P2X7 Receptor |
| 抗原物种 | Human |
| 抗原 | YETNKVTRIQSMNY-C |
| 偶联标记 | Un-conjugated |
| 別名 | ATP receptor; P2X7; P2X purinoceptor 7; P2Z receptor; Purinergic receptor |
应用说明
| 应用建议 |
|
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|---|---|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by antigen affinity chromatography. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 背景介绍 | The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010] |
| 研究领域 | Neuroscience antibody |
| 预测分子量 | 69 kDa |
| 翻译后修饰 | Phosphorylation results in its inactivation. ADP-ribosylation at Arg-125 is necessary and sufficient to activate P2RX7 and gate the channel. Palmitoylation of several cysteines in the C-terminal cytoplasmic tail is required for efficient localization to cell surface. |
检测图片 (2) Click the Picture to Zoom In
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ARG64981 anti-P2RX7 / P2X7 Receptor antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human brain cortex tissue. Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). The tissue section was stained with ARG64981 anti-P2RX7 / P2X7 Receptor antibody at 3.8 µg/ml dilution followed by AP-staining.
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ARG64981 anti-P2RX7 / P2X7 Receptor antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human kidney tissue. Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). The tissue section was stained with ARG64981 anti-P2RX7 / P2X7 Receptor antibody at 3.75 µg/ml dilution followed by AP-staining.
