ARG54602
anti-P Cadherin antibody [NCC-CAD-299]
anti-P Cadherin antibody [NCC-CAD-299] for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Neuroscience antibody; Signaling Transduction antibody
概述
| 产品描述 | Mouse Monoclonal antibody [NCC-CAD-299] recognizes P Cadherin |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 特异性 | This antibody specifically reacts withhuman P-Cadherin, and inhibits PCadherindependent cell-cell contact |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | NCC-CAD-299 |
| 同位型 | IgG1 |
| 靶点名称 | P Cadherin |
| 抗原物种 | Human |
| 抗原 | Human epidermal carcinomacell line A431. |
| 偶联标记 | Un-conjugated |
| 別名 | PCAD; Cadherin-3; P-cadherin; HJMD; Placental cadherin; CDHP |
应用说明
| 应用说明 | Western blot: 5 - 10 ug/ml, nonreducing and non - heating conditions. Immunohistochemistry: 5 - 10 ug/ml, * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
|---|
属性
| 形式 | Liquid |
|---|---|
| 缓冲液 | 10 mM PBS (pH 7.4) and 1% BSA |
| 稳定剂 | 1% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CDH3 |
| 全名 | cadherin 3, type 1, P-cadherin (placental) |
| 背景介绍 | This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy. [provided by RefSeq, Jul 2008] |
| 生物功能 | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. [UniProt] |
| 研究领域 | Neuroscience antibody; Signaling Transduction antibody |
| 预测分子量 | 91 kDa |
克隆号文献
Self-organization is a dynamic and lineage-intrinsic property of mammary epithelial cells.
Inhib / Human
