ARG41547
anti-Otx1 + Otx2 antibody
anti-Otx1 + Otx2 antibody for ChIP,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Otx1 + Otx2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ChIP, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Otx1 + Otx2 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human Otx1/2. |
| 偶联标记 | Un-conjugated |
| 別名 | Otx1: Orthodenticle homolog 1; Homeobox protein OTX1 Otx2: CPHD6; MCOPS5 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Y79 | ||||||||
| 实际分子量 | ~ 34 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | OTX1; OTX2 |
|---|---|
| 全名 | orthodenticle homeobox 1; orthodenticle homeobox 2 |
| 背景介绍 | Otx1: This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mouse is required for proper brain and sensory organ development and can cause epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] Otx2: This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine. [provided by RefSeq, Jul 2012] |
| 生物功能 | Otx1: Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'. [UniProt] Otx2: Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'. [UniProt] |
| 细胞定位 | Otx1 and Otx2: Nucleus. [UniProt] |
| 预测分子量 | Otx1: 37 kDa Otx2: 32 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG41547 anti-Otx1 + Otx2 antibody WB image
Western blot: Y79 cell lysate stained with ARG41547 anti-Otx1 + Otx2 antibody.
