ARG10529
anti-Osteocalcin antibody [6F9]
anti-Osteocalcin antibody [6F9] for ELISA and Human
Developmental Biology antibody; Signaling Transduction antibody
概述
| 产品描述 | Mouse Monoclonal antibody [6F9] recognizes Osteocalcin |
|---|---|
| 反应物种 | Hu |
| 不反应物种 | Ms, Rat, Bov, Pig, Rb |
| 应用 | ELISA |
| 特异性 | This antibody is not cross-reacting with bovine, rat, mouse, rabbit or pig Osteocalcin. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 6F9 |
| 同位型 | IgG1 |
| 靶点名称 | Osteocalcin |
| 抗原物种 | Human |
| 抗原 | Recombinant Human Osteocalcin with glutathione S-transferase |
| 偶联标记 | Un-conjugated |
| 別名 | OCN; Gamma-carboxyglutamic acid-containing protein; Osteocalcin; OC; Bone Gla protein; BGP |
应用说明
| 应用说明 | Recommended pairs for sandwich immunoassay (capture-detection): ARG10528 - ARG10529 (detects the large NH2- terminal fragment and intact hOC) |
|---|
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS (pH 7.4) and 0.09 % Sodium azide |
| 抗菌剂 | 0.09 % Sodium azide |
| 浓度 | 2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | BGLAP |
| 全名 | bone gamma-carboxyglutamate (gla) protein |
| 背景介绍 | This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015] |
| 生物功能 | Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. [UniProt] |
| 产品亮点 | Related Antibody Duos and Panels: ARG30290 Osteocalcin ELISA Antibody Duo Related products: Osteocalcin antibodies; Osteocalcin ELISA Kits; Osteocalcin Duos / Panels; Anti-Mouse IgG secondary antibodies; |
| 研究领域 | Developmental Biology antibody; Signaling Transduction antibody |
| 预测分子量 | 11 kDa |
| 翻译后修饰 | Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium. |
