ARG54924
anti-OASL antibody
anti-OASL antibody for ELISA,ICC/IF,Western blot and Human,Mouse,Rat
Cell Biology and Cellular Response antibody; Immune System antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes OASL |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ELISA, ICC/IF, WB |
| 特异性 | OASL antibody is human, mouse and rat reactive. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | OASL |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide (17 aa) within the first 50 aa of Human OASL. |
| 偶联标记 | Un-conjugated |
| 別名 | Thyroid receptor-interacting protein 14; p59OASL; TR-interacting protein 14; 2'-5'-OAS-RP; p59 OASL; 2'-5'-oligoadenylate synthase-like protein; p59-OASL; 2'-5'-OAS-related protein; 59 kDa 2'-5'-oligoadenylate synthase-like protein; OASLd; TRIP14; TRIP-14 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Mouse Bladder Tissue Lysate |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # G3V645 Rat 2'-5'-oligoadenylate synthase-like protein 1 Swiss-port # Q15646 Human 2'-5'-oligoadenylate synthase-like protein |
|---|---|
| 基因名称 | OASL |
| 全名 | 2'-5'-oligoadenylate synthetase-like |
| 背景介绍 | OASL (2'-5'-oligoadenylate synthetase-like), also known as p59OASL or TRIP14 (thyroid receptor-interacting protein 14), is a 514 amino acid protein that exists as two alternatively spliced isoforms, designated p56 and p30, and contains two ubiquitin-like domains. It is widely expressed in a variety of tissues and interacts with the ligand binding domain of the thyroid receptor (TR) and is able to bind double-stranded RNA and DNA, possibly playing a role in RNA degradation and the overall inhibition of protein synthesis. Methyl CpG-binding protein 1 (MBD1), which functions as a transcriptional repressor, was identified as a strong p59 OASL interactor. |
| 生物功能 | Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. [UniProt] |
| 研究领域 | Cell Biology and Cellular Response antibody; Immune System antibody |
| 预测分子量 | 59 kDa |
检测图片 (3) Click the Picture to Zoom In
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ARG54924 anti-OASL antibody WB image
Western blot: mouse bladder tissue lysate stained with ARG54924 anti-OASL antibody at 1 ug/ml dilution.
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ARG54924 anti-OASL antibody ICC/IF image
Immunofluorescence: HepG2 cells stained with ARG54924 anti-OASL antibody at 20 ug/ml dilution.
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ARG54924 anti-OASL antibody ICC/IF image
Immunocytochemistry: HepG2 cells stained with ARG54924 anti-OASL antibody at 2.5 ug/ml dilution.
