ARG40518
anti-OAS3 antibody
anti-OAS3 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes OAS3 |
|---|---|
| 反应物种 | Hu |
| 应用 | ICC/IF, IHC-P |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | OAS3 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein corresponding to aa. 424-565 of Human OAS3. |
| 偶联标记 | Un-conjugated |
| 別名 | A; p100OAS; p100 OAS; p100; 2-5'; EC 2.7.7.84; 2-5A synthase 3; 2'-5'-oligoadenylate synthase 3 |
应用说明
| 应用建议 |
|
||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 0.03% Proclin 300 and 50% Glycerol. |
| 抗菌剂 | 0.03% Proclin 300 |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | OAS3 |
| 全名 | 2'-5'-oligoadenylate synthetase 3, 100kDa |
| 背景介绍 | This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008] |
| 生物功能 | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV). [UniProt] |
| 细胞定位 | Cytoplasm. Nucleus. [UniProt] |
| 预测分子量 | 121 kDa |
检测图片 (3) Click the Picture to Zoom In
-
ARG40518 anti-OAS3 antibody ICC/IF image
Immunofluorescence: A549 cells stained with ARG40518 anti-OAS3 antibody at 1: 100 dilution.
-
ARG40518 anti-OAS3 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human brain tissue stained with ARG40518 anti-OAS3 antibody at 1: 100 dilution.
-
ARG40518 anti-OAS3 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human testis tissue stained with ARG40518 anti-OAS3 antibody at 1: 100 dilution.
