ARG40104
anti-Neuroserpin antibody
anti-Neuroserpin antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Neuroserpin |
|---|---|
| 反应物种 | Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Neuroserpin |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 181-410 of Human Neuroserpin (NP_005016.1). |
| 偶联标记 | Un-conjugated |
| 別名 | Peptidase inhibitor 12; neuroserpin; Neuroserpin; Serpin I1; PI12; PI-12 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Rat brain and Mouse brain | ||||||
| 实际分子量 | 46 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SERPINI1 |
| 全名 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 |
| 背景介绍 | This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] |
| 生物功能 | Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator. [UniProt] |
| 细胞定位 | Secreted. Cytoplasmic vesicle, secretory vesicle lumen. Perikaryon. [UniProt] |
| 预测分子量 | 46 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG40104 anti-Neuroserpin antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat brain stained with ARG40104 anti-Neuroserpin antibody at 1:200 dilution.
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ARG40104 anti-Neuroserpin antibody WB image
Western blot: 25 µg of Rat brain and Mouse brain lysates stained with ARG40104 anti-Neuroserpin antibody at 1:1000 dilution.
