ARG42345
anti-Nectin 2 antibody [R2.525] (PE)
anti-Nectin 2 antibody [R2.525] (PE) for Flow cytometry and Human
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [R2.525] recognizes Nectin 2 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody R2.525 recognizes an extracellular epitope on CD112, a type I transmembrane glycoprotein expressed by myelomonocytic and megakaryocytic cells, and by CD34+ hematopoietic progenitors. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | R2.525 |
| 同位型 | IgG1, kappa |
| 靶点名称 | Nectin 2 |
| 抗原物种 | Human |
| 抗原 | NIH/3T3 cells transfected with Human Nectin 2. |
| 偶联标记 | PE |
| 別名 | PVRR2; Nectin-2; HveB; PRR2; HVEB; CD antigen CD112; CD112; Poliovirus receptor-related protein 2; Herpes virus entry mediator B; Herpesvirus entry mediator B |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PVRL2 |
| 全名 | poliovirus receptor-related 2 (herpesvirus entry mediator B) |
| 背景介绍 | This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
| 生物功能 | Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005). (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV). [UniProt] |
| 细胞定位 | Cell membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 58 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG42345 anti-Nectin 2 antibody [R2.525] (PE) FACS image
Flow Cytometry: Separation of Caco-2 cells stained with ARG42345 anti-Nectin 2 antibody [R2.525] (PE) (10 µl reagent / 10^6 cells in 100 µl of cell suspension) (red-filled) from Caco-2 cells stained with ARG65337 Mouse IgG1 Kappa Isotype Control antibody [MOPC-21] (PE) at 5 µg/ml dilution (black-dashed).
