ARG56140
anti-Nav1.7 Na+ Channel antibody [S68-6]
anti-Nav1.7 Na+ Channel antibody [S68-6] for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat,Hamster
概述
| 产品描述 | Mouse Monoclonal antibody [S68-6] recognizes Nav1.7 Na+ Channel |
|---|---|
| 反应物种 | Hu, Ms, Rat, Hm |
| 应用 | IHC-P, WB |
| 特异性 | This antibody recognizes Human, Mouse, and Rat Nav1.7. It does not cross-react with other Nav channels. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | S68-6 |
| 同位型 | IgG1 |
| 靶点名称 | Nav1.7 Na+ Channel |
| 抗原物种 | Human |
| 抗原 | Fusion protein around aa. 1751-1946 (cytoplasmic C-terminus) of Human Nav1.7 |
| 偶联标记 | Un-conjugated |
| 別名 | Sodium channel protein type 9 subunit alpha; Nav1.7; PN1; Voltage-gated sodium channel subunit alpha Nav1.7; HSAN2D; NENA; SFNP; NE-NA; hNE-Na; ETHA; Neuroendocrine sodium channel; GEFSP7; Peripheral sodium channel 1; Sodium channel protein type IX subunit alpha; FEB3B |
应用说明
| 应用建议 |
|
||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 0.09% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.09% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SCN9A |
| 全名 | sodium channel, voltage gated, type IX alpha subunit |
| 背景介绍 | This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq, Aug 2009] |
| 生物功能 | Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain (By similarity). [UniProt] |
| 预测分子量 | 226 kDa |
| 翻译后修饰 | Phosphorylation at Ser-1490 by PKC in a highly conserved cytoplasmic loop increases peak sodium currents. Ubiquitinated by NEDD4L; which may promote its endocytosis. Does not seem to be ubiquitinated by NEDD4. |
检测图片 (1) Click the Picture to Zoom In
-
ARG56140 anti-Nav1.7 Na+ Channel antibody [S68-6] IHC-P image
Immunohistochemistry: Mouse brain lysate stained with ARG56140 anti-Nav1.7 Na+ Channel antibody [S68-6] at 1 µg/ml dilution.
