ARG44477
anti-NUMBL antibody
anti-NUMBL antibody for Flow cytometry,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes NUMBL |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | FACS, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | NUMBL |
| 抗原物种 | Human |
| 抗原 | Human NUMBL recombinant protein |
| 偶联标记 | Un-conjugated |
| 別名 | NUMBL; NUMB Like Endocytic Adaptor Protein; NUMBLIKE; NUMB-R; TNRC23; CTG3a; CAG3A; NUMBR; Numb-Related Protein; Numb-Like Protein; Numb (Drosophila) Homolog-Like; Numb Homolog-Like; Numb-R; NBL |
应用说明
| 应用建议 |
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| 应用说明 | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified with Immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | NUMBL |
| 全名 | NUMB Like Endocytic Adaptor Protein |
| 背景介绍 | Involved in cytokine-mediated signaling pathway and protein metabolic process. Predicted to be active in cytoplasm. |
| 生物功能 | Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. |
| 细胞定位 | Cytoplasm |
| 预测分子量 | 65 kDa |
| 翻译后修饰 | Phosphoprotein |
检测图片 (4) Click the Picture to Zoom In
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ARG44477 anti-NUMBL antibody WB image
Western blot: HeLa and U-87 MG stained with ARG44477 anti-NUMBL antibody at 0.5 μg/mL dilution.
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ARG44477 anti-NUMBL antibody FACS image
Flow Cytometry: U87 stained with ARG44477 anti-NUMBL antibody at 1 μg/10^6 cells dilution.
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ARG44477 anti-NUMBL antibody WB image
Western blot: Rat brain stained with ARG44477 anti-NUMBL antibody at 0.5 μg/mL dilution.
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ARG44477 anti-NUMBL antibody WB image
Western blot: Mouse brain and Mouse lung stained with ARG44477 anti-NUMBL antibody at 0.5 μg/mL dilution.
