ARG10406
anti-NT-proBNP antibody [11D1]
anti-NT-proBNP antibody [11D1] for Western blot and Human
Cell Biology and Cellular Response antibody; Signaling Transduction antibody
概述
| 产品描述 | Mouse Monoclonal antibody [11D1] recognizes NT-proBNP |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 11D1 |
| 同位型 | IgG1 |
| 靶点名称 | NT-proBNP |
| 抗原物种 | Human |
| 抗原 | Synthetic N-terminal pro brain natriuretic peptide (NT-proBNP), corresponding to aa. 28-45 |
| 偶联标记 | Un-conjugated |
| 別名 | 4-27; Natriuretic peptides B; 1-28; 1-29; 5-32; BNP; 1-32; 1-30; BNP-32; 5-29; 2-31; 4-30; 4-31; 4-32; 3-29; Gamma-brain natriuretic peptide; 3-30; 5-31; 3-32; 4-29 |
应用说明
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A affinity purified. |
| 缓冲液 | PBS (pH 7.4) and 0.1% Sodium azide |
| 抗菌剂 | 0.1% Sodium azide |
| 浓度 | 1.0-2.0 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | NPPB |
| 全名 | natriuretic peptide B |
| 背景介绍 | This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014] |
| 生物功能 | Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. [UniProt] |
| 研究领域 | Cell Biology and Cellular Response antibody; Signaling Transduction antibody |
| 预测分子量 | 15 kDa |
| 翻译后修饰 | The brain natriuretic peptide 32 form is cleaved at Pro-104 by the prolyl endopeptidase FAP (seprase) activity (in vitro). |
检测图片 (2) Click the Picture to Zoom In
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ARG10406 anti-NT-proBNP antibody [11D1] WB image
Western blot: Human recombinant NT-proBNP expressed in E. coli stained with 1) ARG10408 anti-NT-proBNP antibody [15F11] and 2) ARG10406 anti-NT-proBNP antibody [11D1], after Tricine-SDS gel electrophoresis.
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ARG10406 anti-NT-proBNP antibody [11D1] WB image
Western blot: Human recombinant proBNP expressed in mammalian cells stained with 1) ARG10408 anti-NT-proBNP antibody [15F11] and 2) ARG10406 anti-NT-proBNP antibody [11D1], after Tricine-SDS gel electrophoresis. ARG10406 does not recognize glycosylated proBNP expressed in the mammalian cell line.
