ARG55719
anti-NSMCE2 / NSE2 antibody
anti-NSMCE2 / NSE2 antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes NSMCE2 / NSE2 |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | NSMCE2 / NSE2 |
| 抗原 | Synthetic peptide (15 aa) within aa. 170-220 of Human NSMCE2 / NSE2. |
| 偶联标记 | Un-conjugated |
| 別名 | hMMS21; E3 SUMO-protein ligase NSE2; EC 6.3.2.-; NSE2; MMS21; Non-SMC element 2 homolog; C8orf36; Non-structural maintenance of chromosomes element 2 homolog; MMS21 homolog; ZMIZ7 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | 293 cell lysate |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to 1-2 weeks. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | NSMCE2 |
| 全名 | NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase |
| 生物功能 | E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase and mitotic progression. [UniProt] |
| 预测分子量 | 28 kDa |
| 翻译后修饰 | Sumoylated, possibly via autosumoylation. |
检测图片 (1) Click the Picture to Zoom In
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ARG55719 anti-NSMCE2 / NSE2 antibody WB image
Western blot: 293 cell lysate stained with ARG55719 anti-NSMCE2 / NSE2 antibody at (A) 0.5 and (B) 1 µg/ml dilution.
