ARG44884
anti-NSMCE1 antibody
anti-NSMCE1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human
概述
| 产品描述 | Mouse Monoclonal antibody recognizes NSMCE1 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, IP, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG1 |
| 靶点名称 | NSMCE1 |
| 抗原物种 | Human |
| 抗原表位 | MQGSTRRMGV MTDVHRRFLQ LLMTHGVLEE WDVKRLQTHC YKVHDRNATV DKLEDFINNI NSVLESLYIE IKRGVTEDDG RPIYALVNLA TTSISKMATD FAENELDLFR KALELIIDSE TGFASSTNIL NLVDQLKGKK MRKKEAEQVL QKFVQNKWLI EKEGEFTLHG RAILEMEQYI RETYPDAVKI CNICHSLLIQ GQSCETCGIR MHLPCVAKYF QSNAEPRCPH CNDYWPHEIP KVFDPEKERE SGVLKSNKKS LRSRQH |
| 偶联标记 | Un-conjugated |
| 別名 | NSMCE1; NSE1 Homolog, SMC5-SMC6 Complex Component; NSE1; Non-Structural Maintenance Of Chromosomes Element 1 Homolog; Non-SMC Element 1 Homolog; Non-SMC Element 1 Homolog (S. Cerevisiae); EC 2.3.2.27 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A purification |
| 缓冲液 | PBS with 0.09% sodium azide |
| 抗菌剂 | 0.09% sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q8WV22 Human Non-structural maintenance of chromosomes element 1 homolog |
|---|---|
| 基因名称 | NSMCE1 |
| 全名 | NSE1 Homolog, SMC5-SMC6 Complex Component |
| 背景介绍 | Enables protein dimerization activity and ubiquitin protein ligase activity. Involved in positive regulation of response to DNA damage stimulus. Located in nucleoplasm. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Apr 2022] |
| 生物功能 | MAGEF1-NSMCE1 ubiquitin ligase promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors. [Uniprot] |
| 细胞定位 | Chromosome, Nucleus, Telomere. [Uniprot] |
| 翻译后修饰 | Phosphoprotein, Ubl conjugation. [Uniprot] |
检测图片 (3) Click the Picture to Zoom In
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ARG44884 anti-NSMCE1 antibody IHC-P image
Immunohistochemistry: Human heart muscle stained with ARG44884 anti-NSMCE1 antibody at 5 µg/mL dilution.
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ARG44884 anti-NSMCE1 antibody WB image
Western blot: Jurkat stained with ARG44884 anti-NSMCE1 antibody at 1 µg/mL dilution.
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ARG44884 anti-NSMCE1 antibody IP image
Immunoprecipitation: Jurkat lysate immunoprecipitated with 2.5 µg of ARG44884 anti-NSMCE1 antibody.
