ARG57936
anti-NRG4 antibody
anti-NRG4 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes NRG4 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | NRG4 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-115 of Human NRG4 (NP_612640.1). |
| 偶联标记 | Un-conjugated |
| 別名 | Pro-neuregulin-4, membrane-bound isoform; NRG-4; Pro-NRG4; HRG4 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q8WWG1 Human Pro-neuregulin-4, membrane-bound isoform Swiss-port # Q9WTX4 Mouse Pro-neuregulin-4, membrane-bound isoform |
|---|---|
| 基因名称 | NRG4 |
| 全名 | neuregulin 4 |
| 背景介绍 | The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008] |
| 生物功能 | Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity). [UniProt] |
| 细胞定位 | Cell membrane, Secreted, Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 13 kDa |
| 翻译后修饰 | Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. Extensive glycosylation precedes the proteolytic cleavage. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG57936 anti-NRG4 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human stomach stained with ARG57936 anti-NRG4 antibody at 1:100 dilution.
