ARG56717
anti-NRG1 / Heregulin beta 1 antibody
anti-NRG1 / Heregulin beta 1 antibody for ELISA,Neutralizing,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes NRG1 / Heregulin beta 1 |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA, Neut, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | NRG1 / Heregulin beta 1 |
| 抗原物种 | Human |
| 抗原 | E.coli derived Recombinant Human Heregulinβ-1. (SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE) |
| 偶联标记 | Un-conjugated |
| 別名 | Sensory and motor neuron-derived factor; Heregulin; GGF2; Glial growth factor; Acetylcholine receptor-inducing activity; SMDF; ARIA; NRG1-IT2; Neu differentiation factor; HRGA; NDF; Breast cancer cell differentiation factor p45; HGL; GGF; MSTP131; Pro-NRG1; HRG; MST131; HRG1; Pro-neuregulin-1, membrane-bound isoform |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.2) |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q02297 Human Pro-neuregulin-1, membrane-bound isoform |
|---|---|
| 基因名称 | NRG1 |
| 全名 | neuregulin 1 |
| 背景介绍 | The protein encoded by this gene is a membrane glycoprotein that that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Jun 2014] |
| 生物功能 | Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. [UniProt] |
| 预测分子量 | 70 kDa |
| 翻译后修饰 | Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. N- and O-glycosylated. Extensive glycosylation precedes the proteolytic cleavage (By similarity). |
检测图片 (3) Click the Picture to Zoom In
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ARG56717 anti-NRG1 / Heregulin beta 1 antibody WB image
Western blot: 250 - 0.24 ng of Human Heregulin-β1 stained with ARG56717 anti-NRG1 / Heregulin beta 1 antibody, under reducing conditions.
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ARG56717 anti-NRG1 / Heregulin beta 1 antibody WB image
Western blot: 250 - 0.24 ng of Human Heregulin-β1 stained with ARG56717 anti-NRG1 / Heregulin beta 1 antibody, under non-reducing conditions.
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ARG56717 anti-NRG1 / Heregulin beta 1 antibody standard curve image
Sandwich ELISA: ARG56717 anti-NRG1 / Heregulin beta 1 antibody as a capture antibody at 0.5 - 2.0 µg/ml combined with ARG56826 anti-Heregulin beta1 antibody (Biotin) as a detection antibody. Results of a typical standard run with optical density.
