ARG58207
anti-NRF1 antibody
anti-NRF1 antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
参考文献1
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes NRF1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | FACS, ICC/IF, IHC-P, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | NRF1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from Human NRF1. |
| 偶联标记 | Un-conjugated |
| 別名 | NRF-1; Nuclear respiratory factor 1; Alpha palindromic-binding protein; ALPHA-PAL; Alpha-pal |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||||
| 阳性对照 | U-87 MG | ||||||||||||
| 实际分子量 | ~ 68 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | NRF1 |
| 全名 | nuclear respiratory factor 1 |
| 背景介绍 | This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014] |
| 生物功能 | Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. [UniProt] |
| 预测分子量 | 54 kDa |
| 翻译后修饰 | Phosphorylation enhances DNA binding. [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG58207 anti-NRF1 antibody ICC/IF image
Immunofluorescence: 293T cells stained with ARG58207 anti-NRF1 antibody at 1:250 dilution.
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ARG58207 anti-NRF1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded tonsil tissue stained with ARG58207 anti-NRF1 antibody.
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ARG58207 anti-NRF1 antibody WB image
Western blot: U-87 MG cell lysate stained with ARG58207 anti-NRF1 antibody.
文献引用
Associations between the Nrf2/Keap1 pathway and mitochondrial functions in colorectal cancer are affected by metastasis.
WB / Human
