ARG43839
anti-NRAMP1 / SLC11A1 Antibody
anti-NRAMP1 / SLC11A1 Antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal Antibody recognizes NRAMP1 / SLC11A1 |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SLC11A1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide between 250-276 of human NRAMP1/SLC11A1 |
| 偶联标记 | Un-conjugated |
| Protein Full name | Natural resistance-associated macrophage protein 1 |
| 別名 | SLC11A1; Solute Carrier Family 11 Member 1; Natural Resistance-Associated Macrophage Protein 1; NRAMP1; NRAMP; LSH; Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporter), Member 1; Leishmaniasis Resistance; NRAMP 1 |
应用说明
| 应用建议 |
|
||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification. |
| 缓冲液 | PBS with 0.09% sodium azide |
| 抗菌剂 | 0.09% sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P49279 Human Natural resistance-associated macrophage protein 1 |
|---|---|
| 基因名称 | 6556 |
| 全名 | Solute Carrier Family 11 Member 1 |
| 背景介绍 | This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. |
| 生物功能 | Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe2+ and Mn2+, cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes. |
| 细胞定位 | Membrane |
| 预测分子量 | 60 kDa |
| 翻译后修饰 | Glycoprotein |
检测图片 (1) Click the Picture to Zoom In
-
ARG43839 anti-NRAMP1/SLC11A1 Antibody WB image
Western blot: Human Liver stained with ARG43839 anti-NRAMP1/SLC11A1 Antibody antibody at 1:1000.
