ARG59039
anti-NR3C2 / Mineralocorticoid Receptor antibody
anti-NR3C2 / Mineralocorticoid Receptor antibody for Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes NR3C2 / Mineralocorticoid Receptor |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 预测物种 | Chk |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | NR3C2 / Mineralocorticoid Receptor |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to aa. 950-984 of Human NR3C2 (HALKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK). |
| 偶联标记 | Un-conjugated |
| 別名 | NR3C2VIT; MR; MLR; Nuclear receptor subfamily 3 group C member 2; Mineralocorticoid receptor; MCR |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide and 5% BSA. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | NR3C2 |
| 全名 | nuclear receptor subfamily 3, group C, member 2 |
| 背景介绍 | This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] |
| 生物功能 | Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. [UniProt] |
| 细胞定位 | Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein. Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane. [UniProt] |
| 预测分子量 | 107 kDa |
| 翻译后修饰 | Phosphorylated. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG59039 anti-NR3C2 / Mineralocorticoid Receptor antibody WB image
Western blot: 50 µg of samples under reducing conditions. Rat kidney, Mouse kidney, HeLa and A431 lysates stained with ARG59039 anti-NR3C2 / Mineralocorticoid Receptor antibody at 0.5 µg/ml, overnight at 4°C.
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ARG59039 anti-NR3C2 / Mineralocorticoid Receptor antibody WB image
Western blot: 50 µg of samples under reducing conditions. Mouse brain and Rat brain lysates stained with ARG59039 anti-NR3C2 / Mineralocorticoid Receptor antibody at 0.5 µg/ml, overnight at 4°C.
