ARG64095
anti-NR1H4 / Farnesoid X Receptor antibody
anti-NR1H4 / Farnesoid X Receptor antibody for Western blot and Human
Gene Regulation antibody; Metabolism antibody; Signaling Transduction antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes NR1H4 / Farnesoid X Receptor |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | NR1H4 / Farnesoid X Receptor |
| 抗原物种 | Human |
| 抗原 | KSCREKTELTPDQQ |
| 偶联标记 | Un-conjugated |
| 別名 | BAR; Farnesoid X-activated receptor; Retinoid X receptor-interacting protein 14; HRR-1; HRR1; RIP14; RXR-interacting protein 14; FXR; Bile acid receptor; Nuclear receptor subfamily 1 group H member 4; Farnesol receptor HRR-1 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by antigen affinity chromatography. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 背景介绍 | This gene encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] |
| 研究领域 | Gene Regulation antibody; Metabolism antibody; Signaling Transduction antibody |
| 预测分子量 | 56 kDa |
| 翻译后修饰 | Acetylated by EP300. Lys-227 as is the major acetylation site for EP300; the dynamicly regulated acetylation inhibits heterodimerization with RXRA and transactivation activity. Deacetylated by SIRT1. Methylation may increase transactivation of target genes. Phosphorylation by PKC/PRKCA increases transactivation activity by promoting association with PPARGC1A. Sumoylated upon ligand binding. |
检测图片 (1) Click the Picture to Zoom In
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ARG64095 anti-NR1H4 / Farnesoid X Receptor antibody WB image
Western blot: Human Lung lysate (35 µg protein in RIPA buffer) stained with ARG64095 anti-NR1H4 / Farnesoid X Receptor antibody at 1 µg/ml dilution.
