ARG43152
anti-NPLOC4 antibody
anti-NPLOC4 antibody for ICC/IF,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes NPLOC4 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | NPLOC4 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-270 of Human NPLOC4 (NP_060391.2). |
| 偶联标记 | Un-conjugated |
| 別名 | Nuclear protein localization protein 4 homolog; NPL4; Protein NPL4 |
应用说明
| 预测反应性说明 | Rat | ||||||
|---|---|---|---|---|---|---|---|
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Mouse lung | ||||||
| 实际分子量 | ~ 68 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | NPLOC4 |
| 全名 | NPL4 homolog, ubiquitin recognition factor |
| 生物功能 | The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729). [UniProt] |
| 细胞定位 | Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus. Note=Associated with the endoplasmic reticulum and nuclear. [UniProt] |
| 预测分子量 | 68 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG43152 anti-NPLOC4 antibody ICC/IF image
Immunofluorescence: U2OS cells stained with ARG43152 anti-NPLOC4 antibody at 1:100 dilution.
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ARG43152 anti-NPLOC4 antibody WB image
Western blot: 25 µg of Mouse lung lysate stained with ARG43152 anti-NPLOC4 antibody at 1:3000 dilution.
