anti-NOX2 / gp91phox antibody
anti-NOX2 / gp91phox antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Cancer antibody; Immune System antibody; Metabolism antibody
|产品描述||Rabbit Polyclonal antibody recognizes NOX2 / gp91phox|
|反应物种||Hu, Ms, Rat|
|应用||ICC/IF, IHC-P, WB|
|靶点名称||NOX2 / gp91phox|
|抗原||Recombinant protein of Human CYBB (NP_000388.2)|
|別名||Neutrophil cytochrome b 91 kDa polypeptide; gp91-phox; NADPH oxidase 2; Heme-binding membrane glycoprotein gp91phox; 558; CGD91-phox; gp91-1; EC 1.-.-.-; Cytochrome b; GP91-1; IMD34; CGD; GP91-PHOX; AMCBX2; GP91PHOX; NOX2; Cytochrome b-245 heavy chain; p22 phagocyte B-cytochrome; p91-PHOX; Superoxide-generating NADPH oxidase heavy chain subunit; Cytochrome b558 subunit beta|
|应用说明||* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.|
|纯化||Affinity purification with immunogen.|
|缓冲液||PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol|
|抗菌剂||0.02% Sodium azide|
|存放说明||For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.|
|注意事项||For laboratory research only, not for drug, diagnostic or other use.|
|全名||cytochrome b-245, beta polypeptide|
|背景介绍||Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]|
|生物功能||Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. [UniProt]|
|研究领域||Cancer antibody; Immune System antibody; Metabolism antibody|
Phosphorylated on Ser and Thr residues.
检测图片 (3) Click the Picture to Zoom In
ARG55310 anti-NOX2 / gp91phox antibody ICC/IF image
Immunofluorescence: A431 cells stained with ARG55310 anti-NOX2 / gp91phox antibody at 1:100 dilution.
ARG55310 anti-NOX2 / gp91phox antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Mouse brain stained with ARG55310 anti-NOX2 / gp91phox antibody at 1:100 dilution.
ARG55310 anti-NOX2 / gp91phox antibody WB image
Western blot: THP-1 cell lysate stained with ARG55310 anti-NOX2 / gp91phox antibody.