ARG51143
anti-NMDAR2B antibody
anti-NMDAR2B antibody for ICC/IF and Human,Mouse,Rat
Neuroscience antibody; Postsynaptic Receptor antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes NMDAR2B |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | NMDAR2B |
| 抗原物种 | Human |
| 抗原 | Peptide sequence around aa.1472~1476 (H-V-Y-E-K) derived from Human NMDAR2B. |
| 偶联标记 | Un-conjugated |
| 別名 | MRD6; EIEE27; NR2B; hNR3; GluN2B; NR3; N-methyl D-aspartate receptor subtype 2B; Glutamate receptor ionotropic, NMDA 2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl-D-aspartate receptor subunit 3; NMDAR2B |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Antibodies were produced by immunizing rabbits with KLH-conjugated synthetic peptide. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
| 缓冲液 | PBS (without Mg2+ and Ca2+, pH 7.4), 150mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | GRIN2B |
| 全名 | glutamate receptor, ionotropic, N-methyl D-aspartate 2B |
| 背景介绍 | NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. |
| 生物功能 | NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). [UniProt] |
| 研究领域 | Neuroscience antibody; Postsynaptic Receptor antibody |
| 预测分子量 | 166 kDa |
| 翻译后修饰 | Phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity. |
检测图片 (1) Click the Picture to Zoom In
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ARG51143 anti-NMDAR2B antibody ICC/IF image
Immunofluorescence: methanol-fixed HeLa cells stained with anti-NMDAR2B antibody ARG51143.
