ARG46312
anti-NLRP6 antibody
anti-NLRP6 antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes NLRP6 |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | NLRP6 |
| 抗原物种 | Human |
| 抗原 | A 16 amino acid synthetic peptide within aa. 150 - 200 of human NLRP6. |
| 偶联标记 | Un-conjugated |
| 別名 | NLRP6; PAN3; PYPAF5; NACHT, LRR and PYD domains-containing protein 6; CLR11.4; AVR; PYRIN-containing APAF1-like protein 5; NAVR; Angiotensin II/vasopressin receptor; NALP6; NAVR/AVR |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 纯化 | Affinity chromatography purified |
|---|---|
| 缓冲液 | PBS and 0.02% Sodium azide. |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P59044 Human NACHT, LRR and PYD domains-containing protein 6 |
|---|---|
| 基因名称 | NLRP6 |
| 全名 | NLR family, pyrin domain containing 6 |
| 背景介绍 | The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013] |
| 生物功能 | May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine-vasopressin but not angiotensin II and acts as an arginine-vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, inflammation-inducing bacteria such as Prevotella species. May mediate activation of CASP1 via ASC, promote activation of NF-kappa-B and stimulate cAMP accumulation (By similarity). [UniProt] |
| 细胞定位 | Cytoplasm. Inflammasome. Cell membrane. Nucleus membrane. [UniProt] |
| 预测分子量 | 99 kDa |
