ARG43236
anti-NLRP10 / NALP10 antibody
anti-NLRP10 / NALP10 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes NLRP10 / NALP10 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | NLRP10 / NALP10 |
| 抗原物种 | Human |
| 抗原 | A 14-amino acid synthetic peptide within the first 50 amino acids of Human NLRP10 / NALP10. |
| 偶联标记 | Un-conjugated |
| 別名 | CLR11.1; PAN5; Nucleotide-binding oligomerization domain protein 8; NALP10; PYNOD; NACHT, LRR and PYD domains-containing protein 10; NOD8 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | ~ 72 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS and 0.02% Sodium azide. |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q86W26 Human NACHT, LRR and PYD domains-containing protein 10 |
|---|---|
| 基因名称 | NLRP10 |
| 全名 | NLR family, pyrin domain containing 10 |
| 背景介绍 | Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008] |
| 生物功能 | Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (PubMed:15096476). Displays anti-inflammatory activity (PubMed:20393137). Required for immunity against C.albicans infection (By similarity). Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection (PubMed:22672233). Contributes to T-cell-mediated inflammatory responses in the skin (By similarity). Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (PubMed:28766990). Exhibits both ATPase and GTPase activities (PubMed:23861819). [UniProt] |
| 细胞定位 | Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Cytoplasmic protein which is recruited to the cell membrane by NOD1 following invasive bacterial infection. [UniProt] |
| 预测分子量 | 75 kDa |
检测图片 (3) Click the Picture to Zoom In
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ARG43236 anti-NLRP10 / NALP10 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human brain tissue stained with ARG43236 anti-NLRP10 / NALP10 antibody at 10 µg/ml dilution.
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ARG43236 anti-NLRP10 / NALP10 antibody WB image
Western blot: Human brain lysate stained with ARG43236 anti-NLRP10 / NALP10 antibody at 1 µg/ml dilution.
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ARG43236 anti-NLRP10 / NALP10 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human brain tissue stained with ARG43236 anti-NLRP10 / NALP10 antibody at 20 µg/ml dilution.
