ARG45066
anti-NGEF antibody
anti-NGEF antibody for ICC/IF,Western blot and Human,Mouse,Rat,Chicken
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes NGEF |
|---|---|
| 反应物种 | Hu, Ms, Rat, Chk |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | NGEF |
| 抗原物种 | Mouse |
| 抗原 | Ephexin-1 synthetic peptide corresponds to amino acids in the C-terminal region of mouse ephexin-1. This sequence has significant homology to the same region in human and rat ephexin-1, and has low homology to other known proteins. |
| 偶联标记 | Un-conjugated |
| 別名 | NGEF; Neuronal Guanine Nucleotide Exchange Factor; ARHGEF27; Eph-Interacting Exchange Protein; Ephexin-1; Ephexin1; Ephexin |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Antigen Affinity Purified. |
| 缓冲液 | PBS, 0.05% NaN3, 50% Glycerol and 0.1 % BSA. |
| 稳定剂 | 50% Glycerol and 0.1 % BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | NGEF |
| 全名 | Neuronal Guanine Nucleotide Exchange Factor |
| 背景介绍 | Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including activation of GTPase activity; ephrin receptor signaling pathway; and negative regulation of dendritic spine morphogenesis. Predicted to be located in cytosol. Predicted to be active in glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2022] |
| 生物功能 | Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension |
| 细胞定位 | Cell projection, Cytoplasm, Membrane |
| 预测分子量 | 82 kDa |
| 翻译后修饰 | Phosphoprotein |
