ARG43906
anti-NFE2 antibody
anti-NFE2 antibody for ELISA,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes NFE2 |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | NFE2 |
| 抗原物种 | Human |
| 抗原 | Human NFE2 recombinant protein |
| 表达系统 | E.coli |
| 偶联标记 | Un-conjugated |
| Protein Full name | Transcription factor NF-E2 45 kDa subunit |
| 別名 | NFE2; Nuclear Factor, Erythroid 2; NF-E2; Nuclear Factor, Erythroid-Derived 2 45 KDa Subunit; Transcription Factor NF-E2 45 KDa Subunit; Leucine Zipper Protein NF-E2; P45 NF-E2; P45 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified with Immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4 and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q16621 Human Transcription factor NF-E2 45 kDa subunit |
|---|---|
| 基因名称 | NFE2 |
| 全名 | Nuclear Factor, Erythroid 2 |
| 背景介绍 | Enables several functions, including WW domain binding activity; identical protein binding activity; and protein N-terminus binding activity. Contributes to cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including labyrinthine layer blood vessel development; negative regulation of bone mineralization; and negative regulation of syncytium formation by plasma membrane fusion. Part of protein-DNA complex. |
| 生物功能 | Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron. |
| 细胞定位 | Cytoplasm, Nucleus |
| 预测分子量 | 42 kDa |
| 翻译后修饰 | Isopeptide bond, Phosphoprotein, Ubl conjugation |
检测图片 (1) Click the Picture to Zoom In
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ARG43906 anti-NFE2 antibody WB image
Western blot: K562 and HepG2 stained with ARG43906 anti-NFE2 antibody at 0.5 μg/mL dilution.
